New research reveals that individuals who stop using blockbuster slimming jabs like semaglutide or tirzepatide can put back on lost weight much more quickly than those who stop traditional diet and exercise regimens.
Published data in a leading medical journal shows that while overweight people frequently drop about a fifth of their body weight while on the medication, the mass returns at an estimated rate of 0.8 kg per month upon discontinuation.
"Users using these medications should be aware of the risk of fast rebound weight gain when the treatment is stopped," stated expert Dr. Susan Jebb.
Such speed of regain suggests a return to starting weight in about a year and a half.
Analyzing Approaches
The research, which reviewed dozens of trials involving thousands of patients, contrasted the results of GLP-1 agonists with older methods.
Researchers note that individuals who lose weight through dieting generally see a slower weight regain—approximately 0.1 kg a month—after stopping.
The Reason for the Rapid Rebound
Experts suggest the mechanism of the drugs explains the amplified regain.
The injections imitate a body's own chemical called glucagon-like peptide-1, which helps regulate hunger.
"Long-term administration of the hormone concentrations several times higher than the body's typical production might result in the body to generate a reduced amount of its endogenous hormone, and could diminish sensitivity to its actions," said Dr. Adam Collins, a nutrition specialist.
"Withdrawal of this hormone supplement means appetite is no longer kept in check, making overeating much more probable."
A Chronic Condition?
The NHS suggest the injections for individuals with obesity-related medical conditions, alongside prescribed lifestyle changes.
A number of clinicians say that, due to the likelihood of weight regain, the treatment might need to be ongoing.
This perspective is echoed by pharmaceutical companies, who say that the results "underscore the persistent character of obesity," similar to managing diseases like high blood pressure.
User Accounts
Individuals who have come off the medication explain a powerful resurgence of hunger.
"I experienced something flipping and I was suddenly ravenous," recalled an individual.
This challenge is exacerbated if individuals have not established permanent dietary or behavioural changes during therapy.
Widespread Adoption
Figures show that a significant number of people in the UK have used weight-loss jabs in the past year, with demand being substantial.
- Adoption is more common among females than men.
- The 40s and 50s age group shows the greatest level of interest.
- A large proportion obtain the drugs through private prescriptions rather than the NHS.
Ultimately, researchers stress that while the jabs are potent agents for weight loss, they are not a magic cure and lasting health benefits likely depends on ongoing lifestyle management.
